Hippocampal sclerosis, TDP-43, and the duration of the symptoms of dementia of AD patients.

Oscar L LopezJulia KoflerYueFang ChangSarah B BermanJames T BeckerRobert A SweetNeelesh NadkarniRiddhi PatiraM Ilyas KambohAnn D CohenBeth E SnitzLewis H KullerWilliam E Klunk

Published in: Annals of clinical and translational neurology (2020)

HS and TDP-43 are present in early and late onset AD. However, their presence is mainly driven by the duration of symptoms and the presence of LB. This suggests that HS and TDP-43 are part of the later neuropathological changes in AD.

Keyphrases

late onset
amyotrophic lateral sclerosis
end stage renal disease
early onset
ejection fraction
newly diagnosed
chronic kidney disease
peritoneal dialysis
prognostic factors
mild cognitive impairment
sleep quality
physical activity
patient reported outcomes
cognitive impairment
brain injury
cerebral ischemia