Programmed Cell Death-1: Programmed Cell Death-Ligand 1 Interaction Protects Human Cardiomyocytes Against T-Cell Mediated Inflammation and Apoptosis Response In Vitro.

Woan Ting TayYi-Hsien FangSuet Theng BehYen-Wen LiuLing-Wei HsuChia-Jui YenPing-Yen Liu

Published in: International journal of molecular sciences (2020)

PD-L1 expression on cardiomyocytes suppressed T-cell function. Blockade of PD-1 by nivolumab enhanced cardiomyocyte inflammation and apoptosis through the enhancement of T-cell response towards cardiomyocytes.

Keyphrases

oxidative stress
high glucose
endothelial cells
endoplasmic reticulum stress
cell cycle arrest
cell death
angiotensin ii
induced pluripotent stem cells