Central administration of sodium-glucose cotransporter-2 inhibitors increases food intake involving adenosine monophosphate-activated protein kinase phosphorylation in the lateral hypothalamus in healthy rats.
Kenji TakedaHiraku OnoKo IshikawaTomohiro OhnoJin KumagaiHidetoshi OchiaiAi MatumotoHidetaka YokohYoshiro MaezawaKoutaro YokotePublished in: BMJ open diabetes research & care (2021)
SGLT2 inhibitors in the CNS increase food intake. SGLT2 activity in the CNS may regulate food intake through AMPK phosphorylation in the lateral hypothalamic area.