Growth and CD4 patterns of adolescents living with perinatally acquired HIV worldwide, a CIPHER cohort collaboration analysis.
null nullJulie JessonSiobhan CrichtonMatteo QuartagnoMarcel YotebiengElaine J AbramsKulkanya ChokephaibulkitSophie Le CoeurMarie-Hélène Aké-AssiKunjal PatelJorge PintoMary PaulRachel VreemanMary-Ann DaviesJihane Ben-FarhatRussell Van DykeAli JuddLynne M MofensonMarissa VicariGeorge SeageLinda Gail BekkerShaffiq EssajeeDiana GibbMartina PenazzatoIntira Jeannie CollinsKara Wools-KaloustianAmy SlogroveKathleen M PowisPaige WilliamsMogomotsi MatshabaLineo ThahanePhoebe NyasuluBhekumusa LukheleLumumba MwitaAdeodata Kekitiinwa-RukyalekereSebastian WanlessTessa GoetghebuerClaire ThorneJosiane WarszawskiLuisa GalliAnnemarie M C van RossumCarlo GiaquintoMagdalena MarczynskaLaura MarquesFilipa PrataLuminita EneLyuba OkhonskayaMarisa NavarroAntoinette FrickLars NaverChristian R KahlertAlla VolokhaElizabeth ChappellJean William PapeVanessa RouzierAdias MarcelinRegina SucciAnnette H SohnAzar KariminiaAndrew EdmondsPatricia LeloRita LyamuyaEdith Apondi OgaloFrancesca Akoth OdhiamboAndreas D HaasCarolyn Bolton MooreJosephine MuhairweHannock TweyaMariam SyllaMarceline D'AlmeidaLorna RennerMark J AbzugJames OleskeMurli PurswaniChloe TeasdaleHarriet Nuwagaba-BiribonwohaRuth GoodallValeriane LeroyPublished in: Journal of the International AIDS Society (2022)
Growth patterns during adolescence differed substantially by sex and region, while CD4 patterns were similar, with an observed CD4 decline that needs further investigation. Early diagnosis and timely initiation of treatment in early childhood to prevent growth retardation and immunodeficiency are critical to improving APH growth and CD4 outcomes by the time they reach adulthood.