Single-Cell RNA Sequencing Reveals Transcriptional Landscape of Neutrophils and Highlights the Role of TREM-1 in EAE.

Moyuan Quan Huining Zhang Xianxian Han Yongbing Ba Xiaoyang Cui Yanwei Bi Le Yi Bin Li

Published in: Neurology(R) neuroimmunology & neuroinflammation (2024)

Our research provides a comprehensive and precise single-cell atlas of CLNs in EAE, highlighting the role of neutrophils in regulating the periphery immune response. In addition, TREM-1 emerged as an essential regulator of neutrophil migration to CLNs, holding promise as a potential therapeutic target in MS.

Keyphrases

single cell
rna seq
immune response
transcription factor
high throughput
mass spectrometry
multiple sclerosis
gene expression
ms ms
big data
dendritic cells
human health
toll like receptor
machine learning
climate change
artificial intelligence