Mercaptoalbumin Is Associated with Graft Patency in Patients Undergoing Coronary Artery Bypass Grafting.
Maura BrioschiErica GianazzaDaniele AndreiniSaima MushtaqLaura CavallottiFabrizio VegliaCalogero C TedescoGualtiero I ColomboEugenio PicanoGianluca PolvaniElena TremoliAlessandro ParolariCristina BanfiPublished in: Antioxidants (Basel, Switzerland) (2022)
Coronary artery bypass graft (CABG) surgery still represents the gold standard for patients with complex multivessel coronary artery disease. However, graft occlusion still occurs in a significant proportion of CABG conduits, and oxidative stress is currently considered to be a potential contributor. Human serum albumin (HSA) represents the main antioxidant in plasma through its reduced amino acid Cys34, which can efficiently scavenge several oxidants. In a nested case-control study including 36 patients with occluded grafts and 38 age- and sex-matched patients without occlusion, we assessed the levels of the native mercaptoalbumin (HSA-SH) and oxidized thiolated form of albumin (Thio-HSA) in relation with graft occlusion within 5 years after CABG. We found that the plasma level of preoperative HSA-SH was significantly lower in patients with occluded graft at 5 years follow-up than in patients with graft patency. Furthermore, low HSA-SH remained independently associated with graft occlusion even after adjusting for preoperative D-dimer, a well-known marker of activated coagulation recently found to be associated with graft occlusion. In conclusion, the preoperative level of HSA-SH is independently associated with graft occlusion in CABG and represents a measurable and potentially druggable predictor.
Keyphrases
- coronary artery bypass grafting
- coronary artery bypass
- coronary artery disease
- percutaneous coronary intervention
- patients undergoing
- oxidative stress
- newly diagnosed
- amino acid
- end stage renal disease
- minimally invasive
- st elevation myocardial infarction
- st segment elevation myocardial infarction
- acute coronary syndrome
- ejection fraction
- cardiovascular disease
- heart failure
- signaling pathway
- human serum albumin
- peritoneal dialysis
- risk assessment
- patient reported outcomes
- human health
- induced apoptosis
- heat shock
- low density lipoprotein