Stage I-II diffuse large B-cell lymphoma treated with rituximab and chemotherapy with or without radiotherapy.
Michael Sargent BinkleySusan M HinikerSheren YounesChristopher H YooAnjali WignarajahMichael JinH Henry GuoNeel K GuptaYasodha NatkunamRanjana H AdvaniRichard T HoppePublished in: Leukemia & lymphoma (2021)
We set to identify prognostic factors in a retrospective cohort of consecutive patients with stage I-II diffuse large B-cell lymphoma treated with rituximab-chemotherapy with or without radiotherapy from 2001 through 2017 at our institution. We identified 143 patients with median follow-up of 7.7 years. The majority were male (59.4%), had stage II (53.1%), had stage-modified IPI 0-1 (smIPI, 58.1%), and had non-bulky disease (<7 cm, 68.5%). 99 patients (69.2%) received rituximab-chemotherapy followed by radiotherapy, and 44 patients (30.8%) received rituximab-chemotherapy alone. The 5-year progression-free survival (PFS) and overall survival (OS) were 81.2% and 88.9%, respectively. The 5-year PFS for those with smIPI 0-1 versus 2-4 was 89.5% versus 69.7%, respectively (P = 0.005). Bulky disease (≥7 cm) was associated with worse PFS and OS on univariable and multivariable analyses (P < 0.05). Patients with smIPI 0-1 without bulky disease have excellent outcomes. However, patients with smIPI 2-4 or bulky disease have a high risk of progression.
Keyphrases
- diffuse large b cell lymphoma
- prognostic factors
- locally advanced
- epstein barr virus
- end stage renal disease
- newly diagnosed
- free survival
- early stage
- ejection fraction
- radiation therapy
- chronic kidney disease
- rectal cancer
- radiation induced
- peritoneal dialysis
- hodgkin lymphoma
- skeletal muscle
- chronic lymphocytic leukemia
- insulin resistance
- chemotherapy induced