Promotion of a synthetic degradation of activated STAT6 by PARP-1 inhibition: roles of poly(ADP-ribosyl)ation, calpains and autophagy.

Jeffrey WangMohamed A GhonimSalome V IbbaHanh H LuuYucel AydinPeter A GreerA Hamid Boulares

Published in: Journal of translational medicine (2022)

The results demonstrate that poly(ADP-ribosyl)ation plays a critical role in protecting activated STAT6 during Th2 inflammation, which may be synthetically targeted for degradation by inhibiting PARP-1.

Keyphrases

dna damage
oxidative stress
dna repair
signaling pathway
cell proliferation
cell death
endoplasmic reticulum stress
cancer therapy
drug delivery