Constitutive Activation of the Nutrient Sensor mTORC1 in Myeloid Cells Induced by Tsc1 Deletion Protects Mice from Diet-Induced Obesity.
Vivian A PaschoalThiago BelchiorMariane T AmanoMarina Burgos-SilvaAlbert S PeixotoJuliana MagdalonThayna S VieiraMaynara L AndradeMayara F MorenoPatricia ChiminNiels O CâmaraWilliam T FestucciaPublished in: Molecular nutrition & food research (2018)
Constitutive mTORC1 activation in myeloid cells protects mice from HFD-induced obesity, adipose tissue inflammation, and glucose intolerance by promoting macrophage polarization to M2 pro-resolution profile and increasing energy expenditure.