Methionine supplementation for multi-organ dysfunction in MetRS-related pulmonary alveolar proteinosis.
Alice HadchouelDavid DrummondClément PontoizeauLaura AoustMaria-Margarita Hurtado NedelecJamel El BennaElsa GachelinCaroline PerissonClémentine VigierManuel SchiffFlorence LacailleThierry Jo MolinaLaureline BertelootSylvain RenolleauChris OttolenghiJean-Marc TréluyerJacques de BlicChristophe DelacourtPublished in: The European respiratory journal (2021)
Methionine supplementation was associated with important improvements in children with pulmonary alveolar proteinosis related to mutations in the MARS1 gene. This study paves the way for similar strategies for other tRNA synthetase deficiencies.