NLGP counterbalances the immunosuppressive effect of tumor-associated mesenchymal stem cells to restore effector T cell functions.

Tithi GhoshPartha NandiNilanjan GangulyIpsita GuhaAvishek BhuniyaSarbari GhoshAnirban SarkarAkata SahaShayani DasguptaRathindranath BaralAnamika Bose

Published in: Stem cell research & therapy (2019)

NLGP could be a prospective immunotherapeutic agent to control the functions and behavior of highly immunosuppressive TC-MSCs providing optimum CD8+ T cell functions to showcase an important new approach that might be effective in overall cancer treatment.

Keyphrases

mesenchymal stem cells
umbilical cord
bone marrow
dendritic cells
immune response