Bipolaquinones A-J, Immunosuppressive Meroterpenoids from a Soil-Derived Bipolaris zeicola.
Mengting LiuLianghu GuLing ShenXueke ZhangShuang LinYing YeJianping WangZheng-Xi HuYong-Hui ZhangPublished in: Journal of natural products (2021)
Ten new meroterpenoids, bipolaquinones A-J (1-10), and one known congener, isocochlioquinone F (11), were isolated and identified from the fermented rice cultures of a soil-derived fungus, Bipolaris zeicola. The planar structures of 1-10 were elucidated based on extensive spectroscopic analyses (including HRESIMS and 1D and 2D NMR data), and their absolute configurations were determined by single-crystal X-ray diffraction analyses, comparison of experimental electronic circular dichroism (ECD) data, ECD calculations, and hydrolysis reaction. The immunosuppressive activity assay revealed that compounds 2, 3, and 7-10 showed significant inhibitory activity against concanavalin A (ConA)-induced T lymphocyte proliferation with IC50 values ranging from 4.1 to 9.4 μM, which furnished potential lead molecules for the design and development of new immunosuppressants for treating autoimmune-associated diseases.
Keyphrases
- high resolution
- electronic health record
- big data
- magnetic resonance
- high glucose
- signaling pathway
- molecular docking
- high throughput
- solid state
- drug induced
- multiple sclerosis
- single cell
- molecular dynamics
- molecular dynamics simulations
- magnetic resonance imaging
- diabetic rats
- density functional theory
- computed tomography
- endothelial cells
- data analysis
- dual energy
- oxidative stress
- deep learning