miRNA expression profiling of hereditary breast tumors from BRCA1- and BRCA2-germline mutation carriers in Brazil.

Danielle Pessôa-PereiraAdriane Feijó EvangelistaRhafaela Lima CausinRené Aloisio da Costa VieiraLucas Faria Abrahão-MachadoIara Viana Vidigal SantanaVinicius Duval da SilvaKaren Cristina Borba de SouzaRenato José de Oliveira-SilvaGabriela Carvalho FernandesRui Manuel ReisEdenir Inêz PalmeroMárcia Maria Chiquitelli Marques

Published in: BMC cancer (2020)

Our results showed that miRNA expression profiling can differentiate hereditary from sporadic breast tumors and normal breast tissues. These miRNAs were remarkably deregulated in BRCAX hereditary breast cancers. Therefore, miRNA signatures can be used as potential novel diagnostic biomarkers for the prediction of BRCA1/2- germline mutations and may be useful for future clinical management.

Keyphrases

genome wide
dna repair
gene expression
breast cancer risk
young adults
oxidative stress
dna damage
climate change
transcription factor
early onset