Enantioselective Photochemical Organocascade Catalysis.
Łukasz WoźniakGiandomenico MagagnanoPaolo MelchiorrePublished in: Angewandte Chemie (International ed. in English) (2017)
Reported herein is a photochemical cascade process that combines the excited-state and ground-state reactivity of chiral organocatalytic intermediates. This strategy directly converts racemic cyclopropanols and α,β-unsaturated aldehydes into stereochemically dense cyclopentanols with exquisite stereoselectivity. Mechanistic investigations have enabled elucidating the origin of the stereoconvergence, which is governed by a kinetic resolution process.
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