Impact of NF-κB Signaling and Sirtuin-1 Protein for Targeted Inflammatory Intervention.
Sagar DasTuhin MukherjeeSatyajit MohantyNikita NayakPayel MalSumel AshiqueRadheshyam PalSourav MohantoHimanshu SharmaPublished in: Current pharmaceutical biotechnology (2024)
This detailed review disclosed the NF-κB pro-inflammatory gen's activity regulation and explored the therapeutic significance, activation, and inhibition. This study uncovers the structural intricacies of the NF-κB proteins and highlights the key role of SIRT1 in NF-kB signaling pathway regulation. Particularly the Rel Homology Domain (RHD), elucidating interactions and the regulatory mechanisms involving inhibitory proteins like IκB and p100 within the NF-κB signaling cascade. Disruption of the pathway is important in uncontrolled inflammation and immune disorders. This study extensively describes the role connections of canonical and non-canonical signaling pathways of NF-κB with inflammatory and cellular responses. SIRT1 belongs to the class III histone deacetylase, via RelA/p65 deacetylation, it regulates the activity of NF-κB, closely linked with the NAD+/NADH cellular ratio, influencing stress responses, aging processes, gene regulation, and metabolic pathways. This detailed study reveals SIRT1 as a crucial avenue for uncovering the role of imbalanced NF-κB in diabetes, obesity, and atherosclerosis. This study provides valuable knowledge about the therapeutic targets of inflammatory disorders.
Keyphrases
- signaling pathway
- oxidative stress
- pi k akt
- lps induced
- induced apoptosis
- nuclear factor
- type diabetes
- cardiovascular disease
- epithelial mesenchymal transition
- metabolic syndrome
- ischemia reperfusion injury
- inflammatory response
- cell proliferation
- transcription factor
- weight loss
- body mass index
- toll like receptor
- physical activity
- endoplasmic reticulum stress
- weight gain