Molecules of senescent glial cells differentiate Alzheimer's disease from ageing.

Linbin Dai Feng Gao Qiong WangXinyi LvZhaozhao ChengYan WuXianliang ChaiHenrik ZetterbergKaj BlennowAllan I LeveyJiong ShiYong Shennull null

Published in: Journal of neurology, neurosurgery, and psychiatry (2023)

Our findings demonstrated the different patterns of CSF biomarkers related to senescent glial cells between normal ageing and AD, implicating these biomarkers could identify the road node in healthy path off to neurodegeneration and improve the accuracy of clinical AD diagnosis, which would help promote healthy ageing.

Keyphrases

induced apoptosis
cell cycle arrest
neuropathic pain
lymph node
signaling pathway
mild cognitive impairment