Joint association of mammographic density adjusted for age and body mass index and polygenic risk score with breast cancer risk.

Celine M VachonChristopher G ScottRulla M TamimiDeborah J ThompsonPeter A FaschingJennifer StoneMelissa C SoutheyStacey WinhamSara LindströmJenna LilyquistGraham G GilesRoger L MilneRobert J MacInnisLaura BagliettoJingmei LiKamila CzeneManjeet K BollaQin WangJoe DennisLothar HaeberleMikael ErikssonPeter KraftRobert LubenNick WarehamJanet E OlsonAaron NormanEric C PolleyGertraud MaskarinecLoic Le MarchandChristopher A HaimanJohn L HopperFergus J CouchDouglas F EastonPer HallNilanjan ChatterjeeMontse Garcia-Closas

Published in: Breast cancer research : BCR (2019)

The combined associations of the 77-SNP PRS and adjusted density measures are generally well described by multiplicative models, and both risk factors provide independent information on breast cancer risk.

Keyphrases

breast cancer risk
risk factors
genome wide
health information
healthcare
high density
dna methylation
social media