The Co-occurrence of Pediatric Obesity and ADHD: an Understanding of Shared Pathophysiology and Implications for Collaborative Management.
Valerie M O'HaraJennifer L CurranNancy T BrownePublished in: Current obesity reports (2020)
Obesity and ADHD share common brain pathways (hypothalamic, executive, and reward centers) with pathophysiology in these areas manifesting in partial or complete expression of these diseases. Sleep dysfunction, LOC-ED/BED, and anxiety share similar pathways and are associated with this disease dyad. The association of obesity and ADHD with sleep dysfunction, LOC-ED/BED, and anxiety is discussed. An algorithm outlining decision pathways for patients with obesity and with and without ADHD is presented. Future research exploring the complex pathophysiology of both obesity and ADHD as well as co-occurring conditions is needed to develop clinical guidelines and ultimately assist in providing the best evidence-based care.
Keyphrases
- attention deficit hyperactivity disorder
- insulin resistance
- weight loss
- metabolic syndrome
- working memory
- autism spectrum disorder
- type diabetes
- high fat diet induced
- weight gain
- emergency department
- sleep quality
- healthcare
- adipose tissue
- quality improvement
- oxidative stress
- physical activity
- machine learning
- skeletal muscle
- deep learning
- current status
- clinical practice
- depressive symptoms
- brain injury
- chronic pain
- blood brain barrier
- health insurance
- subarachnoid hemorrhage
- cerebral ischemia