Genomic and serologic characterization of enterovirus A71 brainstem encephalitis.
Kristoffer E LeonRyan D SchubertDidac Casas-AlbaIsobel A HawesPrashanth S RamachandranAkshaya RameshJohn E PakWesley WuCarly K CheungEmily D CrawfordLillian M KhanCristian LaunesHannah A SampleKelsey C ZornMaria CabrerizoAna Valero-RelloCharles LangelierCarmen Muñoz-AlmagroJoseph L DerisiMichael R WilsonPublished in: Neurology(R) neuroimmunology & neuroinflammation (2020)
mNGS with VirScan significantly increased the CNS detection of EVs relative to qRT-PCR, and the latter generated an antigenic profile of the acute EV-A71 immune response. Genomic analysis confirmed the close relation of the outbreak EV-A71 and neuroinvasive German EV-A71. A S241P substitution in VP1 was found exclusively in the CSF.
Keyphrases
- immune response
- real time pcr
- liver failure
- respiratory failure
- copy number
- drug induced
- loop mediated isothermal amplification
- aortic dissection
- toll like receptor
- dna methylation
- gene expression
- inflammatory response
- coronavirus disease
- acute respiratory distress syndrome
- disease virus
- respiratory syndrome coronavirus