Sb(V) Kaempferol and Quercetin Derivative Complexes: Synthesis, Characterization and Antileishmanial Activities.

Sara AbdeyazdanMaryam MohajeriSedigheh Saberi Mahmoud Mirzaei Seyed Abdulmajid Ayatollahi Lotfollah Saghaei Seyed Mostafa Ghannadian

Published in: Iranian journal of pharmaceutical research : IJPR (2022)

All flavonol Sb(V) complexes showed higher activity compared to meglumine antimonate in anti-amastigote effect. Inside the host macrophages, by breaking down the complex into antimony and quercetin or kaempferol analogs, the observed antiparasitic effects may have been related to both Sb(V)/Sb(III) conversion and flavonoid antileishmanial activities.

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