Heart failure in patients is associated with downregulation of mitochondrial quality control genes.
T SvagusaS SikiricM MilavicA SepacS SeiwerthD MilicicH GasparovicB BiocinaI RudezZ SutlicS ManolaJ VarvodicM UdovicicM UrlicS IvankovicS PlestinaF PaicA KulicP BakovicFilip SedlićPublished in: European journal of clinical investigation (2023)
Heart failure in patients with ischemic and dilated cardiomyopathy is associated with downregulation of large number of UPRmt, mitophagy, TIM and fusion-fission balance genes. This indicates multiple defects in MQC and represents one of potential mechanisms underlying mitochondrial dysfunction in patients with heart failure.
Keyphrases
- heart failure
- quality control
- end stage renal disease
- cell proliferation
- genome wide
- newly diagnosed
- ejection fraction
- signaling pathway
- oxidative stress
- peritoneal dialysis
- atrial fibrillation
- gene expression
- bioinformatics analysis
- ischemia reperfusion injury
- risk assessment
- nlrp inflammasome
- climate change
- patient reported
- transcription factor
- human health
- genome wide analysis