Combined Treatment with a WNT Inhibitor and the NSAID Sulindac Reduces Colon Adenoma Burden in Mice with Truncated APC.

Maree C FauxJanet WeinstockSophia GogosEmma PratoAlexander I AzimpourRyan O'KeefeYasmin Cathcart-KingAlexandra L GarnhamMatthias ErnstAdele PreaudetMichael ChristieTracy L PutoczkiMichael BuchertAntony W Burgess

Published in: Cancer research communications (2022)

-mutant colon adenoma cells and suggests a strategy for colorectal cancer prevention and new treatments for patients with advanced colorectal cancer.

Keyphrases

induced apoptosis
cell cycle arrest
stem cells
cell proliferation
wild type
endoplasmic reticulum stress
signaling pathway
metabolic syndrome
combination therapy
adipose tissue
insulin resistance
pi k akt