Bispecific immune cell engager enhances the anticancer activity of CD16+ NK cells and macrophages in vitro, and eliminates cancer metastasis in NK humanized NOG mice.

Shahryar Khoshtinat NikkhoiGe YangHajar OwjiMayara Grizotte-LakeRick I CohenLazaro Gil GonzalezMohammad MassumiArash Hatefi

Published in: Journal for immunotherapy of cancer (2024)

Collectively, our in vivo findings underscore BiKE:E5C1's potential as an immune cell engager capable of activating immune cells for cancer cell elimination, thereby expanding the arsenal of available BiKEs for cancer immunotherapy.

Keyphrases

nk cells
papillary thyroid
squamous cell
signaling pathway
high fat diet induced
monoclonal antibody
lymph node metastasis
squamous cell carcinoma
human health
risk assessment
insulin resistance
metabolic syndrome
adipose tissue
skeletal muscle