Antiepileptic Drug Teratogenicity and De Novo Genetic Variation Load.

Piero PeruccaAlison AndersonDana JazayeriAlison HitchcockJanet GrahamMarian TodaroTorbjörn TomsonDina BattinoEmilio PeruccaMeritxell Martinez FerriAnne RochtusLieven LagaeMaria Paola CaneviniElena ZambrelliEllen CampbellBobby P C KoelemanIngrid Eileen Scheffer Samuel Frank BerkovicPatrick KwanSanjay M SisodiyaDavid B GoldsteinSlavé PetrovskiJohn CraigFrank J E VajdaTerence J O'Briennull null

Published in: Annals of neurology (2020)

Our study indicates that prenatal AED exposure does not increase the burden of de novo variants, and that this mechanism is not a major contributor to AED-induced BDs. These results can be incorporated in routine patient counseling. ANN NEUROL 2020;87:897-906.

Keyphrases

pregnant women
drug induced
case report
copy number
emergency department
smoking cessation
risk factors
endothelial cells
stress induced