HMGB1 regulates Th17 cell differentiation and function in patients with psoriasis.

Xiaofeng ZhuYue DouYawen LinGaoping ChuJing WangLei Ma

Published in: Immunity, inflammation and disease (2024)

HMGB1 can contribute to the pathogenesis of psoriasis by regulating Th17 cell differentiation through HMGB1-TLR4-IL-23-RORγt pathway, then promotes IL-17A production and aggravates inflammation process. Targeting HMGB1 may be a possible potential candidate for the immunotherapy of psoriasis.

Keyphrases

oxidative stress
atopic dermatitis
toll like receptor
inflammatory response
nuclear factor
human health