Interleukin-1β-Activated Microvascular Endothelial Cells Promote DC-SIGN-Positive Alternatively Activated Macrophages as a Mechanism of Skin Fibrosis in Systemic Sclerosis.
Paôline LaurentJoelle LapoirieDamien LeleuEmeline LevionnoisCyrielle GrenierBlanca Jurado-MestreEstibaliz LazaroPierre DuffauChristophe RichezJulien SeneschalJean-Luc PellegrinJoel ConstansThierry SchaeverbekeIsabelle DouchetDorothée DulucThomas PradeuCarlo ChizzoliniPatrick BlancoMarie-Elise TruchetetCécile Contin-Bordesnull nullPublished in: Arthritis & rheumatology (Hoboken, N.J.) (2022)
Our findings shed new light on the vicious circle implicating unabated IL-1β secretion, MVEC activation, and the generation of DC-SIGN+ alternatively activated macrophages in the development of skin fibrosis in patients with SSc.