Renal ischemia alters the transcriptomic and epigenetic profile of inflammatory genes in swine scattered tubular-like cells.

Sara KazeminiaXiang Y ZhuHui TangKyra L JordanIshran M SaadiqSandra M HerrmannAlejandro R ChadeMaria V IrazabalLilach Orly Lerman Alfonso Eirin

Published in: Clinical science (London, England : 1979) (2023)

These observations highlight a novel modulatory mechanism of this renal endogenous repair system and support development of epigenetic or anti-inflammatory therapies to preserve the reparative capacity of STCs in individuals with RAS.

Keyphrases

dna methylation
anti inflammatory
gene expression
genome wide
oxidative stress
single cell
rna seq
wild type
genome wide identification