Antibody-Mediated Immunogenicity Against Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) Following Priming, Boosting, and Hybrid Immunity: Insights From 11 Months of Follow-up of a Healthcare Worker Cohort in Israel, December 2020-October 2021.
Michael EdelsteinKarine Wiegler BeirutiHila Ben-AmramNaor Bar-ZeevChristian SussanHani AsulinDavid StraussYounes BathishSalman ZarkaKamal Abu JabalPublished in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2022)
Immunity waned in all age groups and previously infected individuals, reversed by boosting. IgG titers decrease and reinfections in individuals with hybrid immunity (infection + vaccination) suggests they may also require further doses. Our study also highlights the difficulty in determining protective IgG levels.