KV 1.3 channels are novel determinants of macrophage-dependent endothelial dysfunction in angiotensin II-induced hypertension in mice.

Miguel Angel OlivenciaMarta Martínez-CasalesDiego A PerazaAna Belén García-RedondoGema Mondéjar-ParreñoRaquel HernanzMercedes SalaicesÁngel CogolludoMichael W PenningtonCarmen ValenzuelaAna M Briones

Published in: British journal of pharmacology (2021)

We unravelled a new role for KV 1.3 channels in the macrophage-dependent endothelial dysfunction induced by AngII in mice which might be due to modulation of macrophage phenotype.

Keyphrases

angiotensin ii
adipose tissue
high fat diet induced
angiotensin converting enzyme
vascular smooth muscle cells
blood pressure
high glucose
image quality
diabetic rats
insulin resistance
wild type
type diabetes
drug induced
oxidative stress
skeletal muscle
endothelial cells
magnetic resonance
metabolic syndrome