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Folate metabolism biomarkers from two randomised placebo-controlled clinical studies with paroxetine and venlafaxine.

Lucia CarboniBruno DelafontElena IvanchenkoEmiliangelo RattiSusan M LearnedRobert AlexanderEnrico Domenici
Published in: The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry (2020)
Notwithstanding the relatively large number of patients tested, we did not find consistent associations between folate biomarkers and MDD severity, or response to paroxetine and venlafaxine. Our results may be related to the particular study design or clinical population; however, our findings do not support the hypothesis of a dysfunction of one-carbon metabolism in MDD.
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