Multitrait genetic association analysis identifies 50 new risk loci for gastro-oesophageal reflux, seven new loci for Barrett's oesophagus and provides insights into clinical heterogeneity in reflux diagnosis.

Jue-Sheng OngJiyuan AnXikun HanMatthew H LawPriyanka Nandakumarnull nullnull nullJohannes SchumacherInes GockelAnne BohmerJanusz JankowskiClaire PallesCatherine M OlsenRachel E NealeRebecca FitzgeraldAaron P ThriftThomas L VaughanMatthew F BuasDavid A HindsPuya GharahkhaniBradley J Kendall Stuart Macgregor

Published in: Gut (2021)

Our multitrait model identified many novel risk loci for GERD and BE. We present strong evidence for a genetic underpinning of disease heterogeneity in GERD and show that GERD loci associated with depressive symptoms are not strong predictors of BE/EA relative to obesity-driven GERD loci.

Keyphrases

genome wide
dna methylation
genome wide association study
genome wide association
depressive symptoms
copy number
gastroesophageal reflux disease
single cell
metabolic syndrome
weight loss
gene expression
adipose tissue
body mass index
weight gain
skeletal muscle