Adeno-associated virus type 5 infection via PDGFRα is associated with Interstitial lung disease in systemic sclerosis and generates composite peptides and epitopes recognized by the agonistic immunoglobulins present in patients with systemic sclerosis.

Gianluca MoronciniSilvia SvegliatiAntonella GriecoMassimiliano CuccioloniMatteo MozzicafreddoChiara PaoliniSilvia AgarbatiTatiana SpadoniAngela AmoresanoGabriella PintoQingxin ChenDevis BenfaremoCecilia TonniniMartina SenzacquaSilvia AlizziKaren NietoDoreen FinkeNadia ViolaDonatella AmicoMario GalganiStefano GaspariniLina ZuccatostaStefano MenzoMartin MüllerJuergen KleinschmidtAda FunaroAntonio GiordanoAntonio La CavaPeter DorfmullerAntonio AmorosoPiero PucciAntonio PezoneEnrico V AvvedimentoArmando Gabrielli

Published in: Arthritis & rheumatology (Hoboken, N.J.) (2023)

These data link AVV5 with the immune reactivity to endogenous antigens in SSc, and provide a novel element in the pathogenesis of SSc.

Keyphrases

systemic sclerosis
interstitial lung disease
electronic health record
big data
dendritic cells
rheumatoid arthritis
amino acid
machine learning
data analysis