Drug-Penetration Gradients Associated with Acquired Drug Resistance in Patients with Tuberculosis.

Keertan DhedaLaura LendersGesham MagombedzeShashikant SrivastavaPrithvi RajErland ArningPaula AshcraftTeodoro BottiglieriHelen WainwrightTimothy PennelAnthony LinegarLoven MoodleyAnil PooranJotam G PasipanodyaFrederick A SirgelPaul D van HeldenEdward WakelandRobin M WarrenTawanda Gumbo

Published in: American journal of respiratory and critical care medicine (2019)

These data inform interventional strategies relevant to drug delivery, dosing, and diagnostics to prevent the development of acquired resistance. The role of high intracavitary penetration as a biomarker of antibiotic efficacy, when assessing new regimens, requires clarification.

Keyphrases

drug delivery
mycobacterium tuberculosis
electronic health record
adverse drug
cancer therapy
big data
pulmonary tuberculosis
hepatitis c virus
data analysis
human immunodeficiency virus