Ganciclovir therapeutic drug monitoring in transplant recipients.

Anne-Grete MärtsonAngela E EdwinaJohannes G M BurgerhofStefan P BergerAnoek de JoodeKevin DammanErik A M VerschuurenHans BlokzijlMartijn BakkerLambert F SpanTjip S van der WerfDaan J TouwMarieke G G SturkenboomMarjolein KnoesterJan W C Alffenaar

Published in: The Journal of antimicrobial chemotherapy (2021)

This study revealed that a standard weight and kidney function-based dosing regimen resulted in highly variable ganciclovir Cmin and under- and over-exposure were observed in patients on dialysis and in patients with increased renal function. Clearly there is a need to explore the impact of concentration-guided dose adjustments in a prospective study.

Keyphrases

end stage renal disease
chronic kidney disease
peritoneal dialysis
ejection fraction
newly diagnosed
physical activity
body mass index
single cell
weight gain