Examining the Reserve Hypothesis in Parkinson's Disease: A Longitudinal Study.
Pei-Chen LeeFanny ArtaudFlorence Cormier-DequaireOlivier RascolFranck DurifPascal DerkinderenAna-Raquel MarquesFrédéric BourdainJean-Philippe BrandelFernando PicoLucette LacomblezCecilia BonnetChristine Brefel-CourbonFabienne Ory-MagneDavid GrabliStephan KlebeGraziella MangoneHana YouValérie MesnageAlexis BriceMarie VidailhetJean-Christophe CorvolAlexis Elbaznull nullPublished in: Movement disorders : official journal of the Movement Disorder Society (2019)
Higher education is associated with better baseline motor/cognitive function in PD, but not with rate of decline, and with a lower risk of reaching Hoehn and Yahr ≥3 during the follow-up. Our observations are consistent with a passive reserve hypothesis for motor/cognitive symptoms. © 2019 International Parkinson and Movement Disorder Society.