Faecal bacteriome and metabolome profiles associated with decreased mucosal inflammatory activity upon anti-TNF therapy in paediatric Crohn's disease.

Jakub HurychAnna Mascellani BergoTereza LerchovaLucie HlinakovaMichal KubatHana MalcovaDita CebecauerovaJan SchwarzEva KaraskovaTomas HechtRadim VyhnanekLenka ToukalkovaVojtech DotlacilKaterina GreinerovaAnabela CizkovaRudolf HorvathJiri BronskyJaroslav HavlikOndrej HradskyOndrej Cinek

Published in: Journal of Crohn's & colitis (2023)

Our findings suggest that gut mucosal healing is responsible for the bacteriome and metabolome changes observed in CD, rather than any general effect of anti-TNF.

Keyphrases

rheumatoid arthritis
ulcerative colitis
intensive care unit
emergency department
oxidative stress
bone marrow
smoking cessation