A Fibrosis-Independent Hepatic Transcriptomic Signature Identifies Drivers of Disease Progression in Primary Sclerosing Cholangitis.

Yevgeniy GindinChuhan ChungZhaoshi JiangJing Zhu ZhouJun XuAndrew N BillinRobert P MyersZachary GoodmanAbdolamir LandiMichael HoughtonRichard M GreenCynthia LevyKris V KowdleyChristopher L BowlusAndrew J MuirMichael Trauner

Published in: Hepatology (Baltimore, Md.) (2021)

Removing the contribution of fibrosis-related pathways uncovered alterations in the unfolded protein response, which were associated with liver-related complications in PSC.

Keyphrases

genome wide
risk factors
single cell
gene expression
rna seq
amino acid
liver fibrosis
dna methylation
ulcerative colitis