SJPedPanel: A pan-cancer gene panel for childhood malignancies to enhance cancer monitoring and early detection.

Pandurang Kolekar Vidya Balagopal Li Dong Yanling Liu Scott Foy Quang Tran Heather L Mulder Anna L W Huskey Emily M Plyler Zhikai Liang Jingqun Ma Joy Nakitandwe Jiali Gu Maria Namwanje Jamie L Maciaszek Debbie Payne-Turner Saradhi Mallampati Lu Wang John Easton Jeffery M Klco Xiaotu Ma

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2024)

SJPedPanel enables the cost-effective detection of clinically relevant genetic alterations including rearrangements responsible for subtype-defining fusions by targeted sequencing of ~0.15% of human genome for childhood malignancies. It will enhance the analysis of specimens with low tumor burdens for cancer monitoring and early detection.

Keyphrases

papillary thyroid
squamous cell
childhood cancer
genome wide
endothelial cells
lymph node metastasis
squamous cell carcinoma
copy number
gene expression
dna methylation
drug delivery