Genome-wide gene expression analysis of a murine model of prostate cancer progression: Deciphering the roles of IL-6 and p38 MAPK as potential therapeutic targets.

Reem DaoukHisham F BahmadEman SalehAlissar MonzerFarah BalloutHumam KadaraWassim Abou-Kheir

Published in: PloS one (2020)

In summary, our study highlights pathways associated with an augmented malignant phenotype in AI cells and presents new high-potential targets to constrain the aggressive malignancy seen in the castration-resistant PCa.

Keyphrases

prostate cancer
gene expression
genome wide
dna methylation
induced apoptosis
cell cycle arrest
artificial intelligence
machine learning
cell death
oxidative stress
copy number
signaling pathway
risk assessment
pi k akt