Local and Systemic Effects of Porphyromonas gingivalis Infection.
William A ChenYuetan DouHansel M FletcherDanilo S BoskovicPublished in: Microorganisms (2023)
Porphyromonas gingivalis , a gram-negative anaerobe, is a leading etiological agent in periodontitis. This infectious pathogen can induce a dysbiotic, proinflammatory state within the oral cavity by disrupting commensal interactions between the host and oral microbiota. It is advantageous for P. gingivalis to avoid complete host immunosuppression, as inflammation-induced tissue damage provides essential nutrients necessary for robust bacterial proliferation. In this context, P. gingivalis can gain access to the systemic circulation, where it can promote a prothrombotic state. P. gingivalis expresses a number of virulence factors, which aid this pathogen toward infection of a variety of host cells, evasion of detection by the host immune system, subversion of the host immune responses, and activation of several humoral and cellular hemostatic factors.
Keyphrases
- immune response
- gram negative
- oxidative stress
- multidrug resistant
- induced apoptosis
- pseudomonas aeruginosa
- signaling pathway
- escherichia coli
- candida albicans
- cell cycle arrest
- risk assessment
- toll like receptor
- dendritic cells
- inflammatory response
- cystic fibrosis
- biofilm formation
- high glucose
- endoplasmic reticulum stress