Dysfunctional lactate metabolism in human alveolar type II cells from idiopathic pulmonary fibrosis lung explant tissue.

Danforth A NewtonRobyn G LottesRita M RyanDemetri D SpyropoulosJohn E Baatz

Published in: Respiratory research (2021)

These results are consistent with the concept that altered lactate metabolism may be an underlying feature of AEC2 dysfunction in IPF and may be a novel and important target for therapeutic treatment.

Keyphrases

idiopathic pulmonary fibrosis
interstitial lung disease
endothelial cells
machine learning
oxidative stress
induced pluripotent stem cells
deep learning
replacement therapy
smoking cessation