Ester Prodrugs of Malonate with Enhanced Intracellular Delivery Protect Against Cardiac Ischemia-Reperfusion Injury In Vivo.

Hiran A PragLaura PalaDuvaraka Kula-AlwarJohn F MulveyDu LupingTimothy E BeachLee M BootyAndrew R HallAngela LoganVolha SauchankaStuart T CaldwellEllen L RobbAndrew M JamesZhelong XuKourosh Saeb-ParsyRichard C HartleyMichael P MurphyThomas Krieg

Published in: Cardiovascular drugs and therapy (2020)

The rapidly hydrolysed malonate prodrug MAM can protect against cardiac I/R injury in a clinically relevant mouse model.

Keyphrases

ischemia reperfusion injury
mouse model
left ventricular
cancer therapy
heart failure
reactive oxygen species
atrial fibrillation