New methods of modification of α-cyclodextrin.

While being some of the oldest supramolecular hosts, cyclodextrins remain very popular as molecular binders in materials, devices, artificial enzymes and more. The popularity is undoubtedly connected to the ready availability, carbohydrate biomass origin, biodegradability and water solubility of the cyclodextrins. Many of these applications require synthetic modification of the cyclodextrin - at the simplest the attachment of a linker - but also often attachment of several functional groups, lids, bridges etc . Here we review state of the art methods of modifying α-cyclodextrin, which include direct modications of unprotected α-cyclodextrin and protection/deprotection method to partially modified cyclodextrins.