Overcoming scientific barriers in the transition from in vivo to non-animal batch testing of human and veterinary vaccines.
Robin H G A van den BiggelaarMarcel H N HoefnagelRob J VandebrielArjen SlootsCoenraad F M HendriksenWillem van EdenVictor P M G RuttenChristine A JansenPublished in: Expert review of vaccines (2021)
For safety testing, many in vitro alternatives are already available or at an advanced level of development. For potency testing, in vitro alternatives largely comprise immunochemical methods that assess several, but not all critical vaccine properties. One-to-one replacement by in vitro alternatives is not always possible and a combination of methods may be required.
Keyphrases