The 4-aminopiperidine series has limited anti-tubercular and anti-staphylococcus aureus activity.
N Susantha ChandrasekeraTorey AllingMai BaileyAaron KorkegianJames AhnYulia OvechkinaJoshua OdingoTanya Parish
Published in: Journal of negative results in biomedicine (2015)
We were unable to derive any other analogs with MIC < 20 μM against M. tuberculosis. Therefore we conclude that the lack of activity is a liability in this series precluding it from further development.