Genetic Regulation of DNA Methylation Yields Novel Discoveries in GWAS of Colorectal Cancer.

Richard Barfield Jeroen R HuygheMathieu LemireXinyuan DongYu-Ru SuStefanie Brezina Daniel D Buchanan Jane C FigueiredoSteven GallingerMarios GiannakisAndrea Gsur Marc J Gunter Heather Hampel Tabitha A HarrisonJohn L HopperThomas J HudsonChristopher I LiVictor MorenoPolly A NewcombRish K Pai Paul D P PharoahAmanda I PhippsConghui QuRobert S SteinfelderWei Sun Aung-Ko WinSyed H ZaidiPeter T Campbell Ulrike Peters Li Hsu

Published in: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology (2022)

Using genotype, DNAm, and GWAS, we identified four new colorectal cancer risk loci. We studied the landscape of genetic regulation of DNAm via single-SNP and multi-SNP meQTL analyses.

Keyphrases

genome wide
dna methylation
copy number
gene expression
nk cells
single cell
high density
genetic diversity