Visualization of Intratumor Pharmacokinetics of [fam-] Trastuzumab Deruxtecan (DS-8201a) in HER2 Heterogeneous Model Using Phosphor-integrated Dots Imaging Analysis.

Mikiko SuzukiShigehiro YagishitaKiyoshi SugiharaYusuke OgitaniTadaaki NishikawaMayu OhuchiTakashi TeishikataTakahiro JikohYasushi YatabeKan Yonemori Kenji TamuraKosei HasegawaAkinobu Hamada

Published in: Clinical cancer research : an official journal of the American Association for Cancer Research (2021)

Our results suggest that T-DXd is distributed to tumor tissues via trastuzumab in a HER2-dependent manner and then to adjacent HER2-negative areas. We successfully visualized the intratumor distribution of T-DXd and its mechanism of action, the so-called "bystander effect."

Keyphrases

epidermal growth factor receptor
high resolution
gene expression
fluorescent probe
fluorescence imaging
photodynamic therapy
light emitting
tandem mass spectrometry