Severe iatrogenic hypoglycaemia modulates the fibroblast growth factor protein response.

Manjula NandakumarAbu Saleh Md MoinManjunath RamanjaneyaAhmed Al QaissiThozhukat SathyapalanStephen L AtkinAlexandra E Butler

Published in: Diabetes, obesity & metabolism (2022)

Severe transient hypoglycaemia modulated FGF7, 16, 19, 20 and 23 (known to be associated with diabetes), together with FGF18 and 12, not previously reported to be associated with diabetes but that may be important in the pathophysiology of hypoglycaemia; FGF20 remained low at 24 h. Taken together, these data suggest that recurrent hypoglycaemia may contribute to the development of complications through changes in FGF proteins.

Keyphrases

type diabetes
glycemic control
cardiovascular disease
early onset
electronic health record
amino acid
big data
small molecule
drug induced
protein protein
artificial intelligence
data analysis