Approach to screening for Familial Adenomatous Polyposis (FAP) in a cohort of 226 patients with Desmoid-type Fibromatosis (DF): experience of a specialist center in the UK.
E CojocaruS GennatasK ThwayC FisherA SmrkeD StraussA HayesM SmithR L JonesC BensonTerri Patricia McVeighPublished in: Familial cancer (2021)
CTNNB1 ± APC testing and colonoscopy are useful tools for the screening of patients with DF. CTNNB1 molecular testing should be performed in all cases of newly diagnosed DF. Negative CTNNB1 results, alongside clinical assessment, should prompt APC testing and/or colonoscopy.
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