Sex Differences in the Risk of Coronary Heart Disease Associated With Type 2 Diabetes: A Mendelian Randomization Analysis.

Tricia M Peters Michael V Holmes John Brent RichardsTom PalmerVincenzo ForgettaCecilia M LindgrenFolkert W AsselbergsChristopher P NelsonNilesh J SamaniMark I McCarthyAnubha MahajanGeorge Davey SmithMark WoodwardLinda M O'KeeffeSanne A E Peters

Published in: Diabetes care (2020)

This MR analysis supports a causal effect of genetic liability to type 2 diabetes on risk of CHD that is not stronger for women than men. Assuming a lack of bias, these findings suggest that the prevention and management of type 2 diabetes for CHD risk reduction is of equal priority in both sexes.

Keyphrases

type diabetes
cardiovascular disease
glycemic control
insulin resistance
magnetic resonance
polycystic ovary syndrome
gene expression
computed tomography
metabolic syndrome
pregnant women
contrast enhanced